Skip to Content

People

Xiphophorus Genetic Stock Center
Dr. Michael Blanda

Dr. Michael Blanda

e-mail

CV

Professor and Assistant Vice President for Research and Federal Relations

Director Xiphophorus Genetic Stock Center

In addition to his primary roles as Professor and Assistant Vice President for Research and Federal Relations, Dr. Blanda is serving as the Interim Chair of the Xiphophorus Genetic Stock Center.

Dr. Manfred Schartl

Dr. Manfred Schartl

email

CV

Webpage

Scholar in Residence and Research Professor Xiphophorus Genetic Stock Center

My main research interests are the molecular processes in organismic development and their malfunction in cancerogenesis. One major topic is signal transduction and gene regulation in melanoma. I use the Xiphophorus model system and transgenic medaka that develop different types of pigment cell tumors. Besides classical tools for biochemical characterization of signal transduction and transcriptional regulation, I use genome sequencing and RNA-Seq transcriptomics in a comparative approach of fish models with human data to identify new melanoma genes and small non-coding RNAs that are involved in the transition from a benign pigmentary lesion to malignant melanoma. 

Google Scholar

Dr. Yuan Lu

Dr. Yuan Lu

email

CV

Associate Director Xiphophorus Genetic Stock Center

I am interested in studying mechanisms that various species adapted to cope with or repress disease, or disease causal mutations that are similar to human condition, to better understand disease etiology and develop novel strategies in controlling human disease. Specifically, my research program studies genetics and molecular mechanisms that account for tumorigenic negative epistasis of select Xiphophorus interspecies hybrids [i.e., X. hellerii x (X. maculatus X. hellerii)]. Tumor development is a result of segregation between a X. maculatus specific mutant copy of epidermal growth factor receptor (egfr) and co-evolved regulator gene named R(Diff). We recently identified the genetic location and discovered the identity of the R(Diff) . My current research focus is to elucidate mechanisms of egfr suppression by R(Diff). As an oncogene, EGFR mutation and overexpression are present in a majority of human cancers. However, EGFR-targeted cancer therapies suffer from low-response rate and resistance. Characterizing R(Diff) regulation on egfr may lead to novel therapeutic strategies in controlling EGFR-driven cancer. 

NCBI

Dr. Caitlin Gabor

Dr. Caitlin Gabor

e-mail

CV

Webpage

Associate Director Xiphophorus Genetic Stock Center

My research program spans population level questions using conservation physiology and behavioral and evolutionary ecology with fish and amphibians as model organisms. My lab studies the historical forces of natural and sexual selection on speciation in a unisexual-bisexual species complex of live bearing fish from a population, behavioral, genetic and physiological standpoint.

Google Scholar

Markita Savage

Markita Savage

e-mail

Bio

Operational Manager of the Xiphophorus Genetic Stock Center Markita began her employment with the Xiphophorus Genetic Stock Center as a Grant Specialist in 2005 and was promoted to Operational Manager in 2008.  Markita has since been in charge of all daily operations of the Stock Center including Xiphophorus species maintenance as well as maintenance of Japanese medaka (Oryzias latipes) lines housed at the center.